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Compound Detail

CHEMBL387944

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COc1cc(CNc2ncnc3c2ncn3[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)cc(OC)c1

Basic Information

ChEMBL ID CHEMBL387944
Phase Preclinical
Structure Type MOL
InChI Key ZJPZIXQSHLIZLD-NVQRDWNXSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

417.4
MW (Da)
0.07
ALogP
11
HBA
4
HBD
144.0
PSA (Ų)
0.42
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H23N5O6
MW 417.42
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness 0.45

Activity Summary

IC50 1 meas. best 4.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
HL-60
CHEMBL383
IC50 4.7 4.7 20200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
HL-60 IC50 = 20200.0 nM 4.7 Antitumor activity against human HL60 cells after 72 hrs by Calcein AM assay 17418578

Literature References

Data from ChEMBL 36 via Core Engine