Compound Detail
CHEMBL388088
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Basic Information
| ChEMBL ID | CHEMBL388088 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PCOFMUGCMQCFEI-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
218.2
MW (Da)
-0.83
ALogP
7
HBA
0
HBD
70.3
PSA (Ų)
0.62
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 CHEMBL2095188 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of rabbit GSK3 | 16279768 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16279768 | 10.1021/jm040895g | Glycogen synthase kinase-3 | 1 |
| 16279768 | 10.1021/jm040895g | Tyrosine-protein kinase ABL1 | 1 |
| 16279768 | 10.1021/jm040895g | CaM kinase II | 1 |
| 16279768 | 10.1021/jm040895g | Mitogen-activated protein kinase; ERK1/ERK2 | 1 |
| 16279768 | 10.1021/jm040895g | Tyrosine-protein kinase Lck | 1 |
| 16279768 | 10.1021/jm040895g | Epidermal growth factor receptor | 1 |
| 16279768 | 10.1021/jm040895g | Insulin receptor | 1 |
| 16279768 | 10.1021/jm040895g | Dual specificity mitogen-activated protein kinase kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine