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Assay Detail

CHEMBL920549

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Binding
Inhibition of rabbit GSK3
ChEMBL ↗
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Oryctolagus cuniculus
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Glycogen synthase kinase-3 (CHEMBL2095188) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.
Martinez A, Alonso M, Castro A, Dorronsoro I, Gelpí JL, Luque FJ, Pérez C, Moreno FJ.
J Med Chem (2005) 48 : 7103 -7112
PubMed 16279768 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 58 4.87 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL388979 — — 1 6.00
CHEMBL24721 — — 1 5.96
CHEMBL388088 — — 1 5.70
CHEMBL284861 — — 1 5.70
CHEMBL287864 — — 1 5.70
CHEMBL26515 — — 1 5.70
CHEMBL223342 — — 1 5.70
CHEMBL26274 — — 1 5.70
CHEMBL223341 — — 1 5.60
CHEMBL376810 — — 1 5.52
CHEMBL224301 — — 1 5.52
CHEMBL224979 — — 1 5.52
CHEMBL224232 — — 1 5.52
CHEMBL24494 — — 1 5.40
CHEMBL24537 — — 1 5.40
CHEMBL25820 — — 1 5.40
CHEMBL26218 — — 1 5.30
CHEMBL225037 — — 1 5.30
CHEMBL24753 — — 1 5.30
CHEMBL387762 — — 1 5.22
CHEMBL224674 — — 1 5.22
CHEMBL417835 — — 1 5.22
CHEMBL23840 — — 1 5.22
CHEMBL26241 KRM-7777 — 1 5.16
CHEMBL224236 — — 1 5.07
CHEMBL24693 — — 1 5.00
CHEMBL284365 — — 1 5.00
CHEMBL286009 — — 1 5.00
CHEMBL223398 — — 1 4.92
CHEMBL375657 — — 1 4.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL388979 — IC50 = 1000.0 nM 6.00
CHEMBL24721 — IC50 = 1100.0 nM 5.96
CHEMBL388088 — IC50 = 2000.0 nM 5.70
CHEMBL284861 — IC50 = 2000.0 nM 5.70
CHEMBL287864 — IC50 = 2000.0 nM 5.70
CHEMBL26515 — IC50 = 2000.0 nM 5.70
CHEMBL223342 — IC50 = 2000.0 nM 5.70
CHEMBL26274 — IC50 = 2000.0 nM 5.70
CHEMBL223341 — IC50 = 2500.0 nM 5.60
CHEMBL376810 — IC50 = 3000.0 nM 5.52
CHEMBL224301 — IC50 = 3000.0 nM 5.52
CHEMBL224979 — IC50 = 3000.0 nM 5.52
CHEMBL224232 — IC50 = 3000.0 nM 5.52
CHEMBL25820 — IC50 = 4000.0 nM 5.40
CHEMBL24494 — IC50 = 4000.0 nM 5.40
CHEMBL24537 — IC50 = 4000.0 nM 5.40
CHEMBL26218 — IC50 = 5000.0 nM 5.30
CHEMBL225037 — IC50 = 5000.0 nM 5.30
CHEMBL24753 — IC50 = 5000.0 nM 5.30
CHEMBL387762 — IC50 = 6000.0 nM 5.22
CHEMBL224674 — IC50 = 6000.0 nM 5.22
CHEMBL417835 — IC50 = 6000.0 nM 5.22
CHEMBL23840 — IC50 = 6000.0 nM 5.22
CHEMBL26241 KRM-7777 IC50 = 7000.0 nM 5.16
CHEMBL224236 — IC50 = 8500.0 nM 5.07
CHEMBL24693 — IC50 = 10000.0 nM 5.00
CHEMBL286009 — IC50 = 10000.0 nM 5.00
CHEMBL284365 — IC50 = 10000.0 nM 5.00
CHEMBL223398 — IC50 = 12000.0 nM 4.92
CHEMBL375657 — IC50 = 12000.0 nM 4.92
CHEMBL224231 — IC50 = 12000.0 nM 4.92
CHEMBL25829 — IC50 = 25000.0 nM 4.60
CHEMBL224367 — IC50 = 25000.0 nM 4.60
CHEMBL26551 — IC50 = 35000.0 nM 4.46
CHEMBL225554 — IC50 = 35000.0 nM 4.46
CHEMBL387881 — IC50 = 50000.0 nM 4.30
CHEMBL225440 — IC50 = 65000.0 nM 4.19
CHEMBL223343 — IC50 = 100000.0 nM 4.00
CHEMBL224900 — IC50 = 100000.0 nM 4.00
CHEMBL85398 THIAZOLIDINEDIONE IC50 = 100000.0 nM 4.00
CHEMBL390330 AMINORHODANINE IC50 = 100000.0 nM 4.00
CHEMBL224441 RHODANINE-3-ACETIC ACID IC50 = 100000.0 nM 4.00
CHEMBL224043 3-METHYL-RHODANINE IC50 = 100000.0 nM 4.00
CHEMBL224288 — IC50 = 100000.0 nM 4.00
CHEMBL224235 — IC50 = 100000.0 nM 4.00
CHEMBL390546 — IC50 = 100000.0 nM 4.00
CHEMBL122334 HYDANTOIN IC50 = 100000.0 nM 4.00
CHEMBL157999 — IC50 = 100000.0 nM 4.00
CHEMBL24167 — IC50 = 100000.0 nM 4.00
CHEMBL224633 RHODANINE IC50 = 100000.0 nM 4.00