Compound Detail
CHEMBL284365
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Basic Information
| ChEMBL ID | CHEMBL284365 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SGSVNPJHIDULGL-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
298.4
MW (Da)
2.17
ALogP
5
HBA
0
HBD
44.0
PSA (Ų)
0.74
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sortase A CHEMBL5362 | IC50 | 5.16 | 5.025 | 7000.0 | 2 |
| Glycogen synthase kinase-3 CHEMBL2095188 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sortase A | IC50 | = | 7000.0 | nM | 5.16 | Inhibition of Staphylococcus aureus SrtA delta N24 mutant expressed in Escherich... | 32639734 |
| Glycogen synthase kinase-3 beta | IC50 | = | 10000.0 | nM | 5.0 | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | 11881998 |
| Glycogen synthase kinase-3 | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of rabbit GSK3 | 16279768 |
| Sortase A | IC50 | = | 12900.0 | nM | 4.89 | Inhibition of Staphylococcus aureus SrtA delta N24 mutant expressed in Escherich... | 32639734 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32639734 | 10.1021/acs.jmedchem.0c00803 | Sortase A | 2 |
| 11881998 | 10.1021/jm011020u | Glycogen synthase kinase-3 beta | 1 |
| 16279768 | 10.1021/jm040895g | Glycogen synthase kinase-3 | 1 |
| 16279768 | 10.1021/jm040895g | Tyrosine-protein kinase ABL1 | 1 |
| 16279768 | 10.1021/jm040895g | CaM kinase II | 1 |
| 16279768 | 10.1021/jm040895g | Epidermal growth factor receptor | 1 |
| 16279768 | 10.1021/jm040895g | Mitogen-activated protein kinase; ERK1/ERK2 | 1 |
| 16279768 | 10.1021/jm040895g | Dual specificity mitogen-activated protein kinase kinase 1 | 1 |
| 16279768 | 10.1021/jm040895g | Insulin receptor | 1 |
| 16279768 | 10.1021/jm040895g | Tyrosine-protein kinase Lck | 1 |
| 32639734 | 10.1021/acs.jmedchem.0c00803 | Staphylococcus aureus | 1 |
Data from ChEMBL 36 via Core Engine