Compound Detail
CHEMBL122334
HYDANTOIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL122334 |
| Name | HYDANTOIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WJRBRSLFGCUECM-UHFFFAOYSA-N |
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
100.1
MW (Da)
-1.17
ALogP
2
HBA
2
HBD
58.2
PSA (Ų)
0.38
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.21
Ki 2 meas. best 4.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | IC50 | 7.21 | 7.21 | 62.0 | 1 |
| Protein cereblon CHEMBL3763008 | Ki | 4.37 | 4.37 | 43000.0 | 1 |
| Glycogen synthase kinase-3 CHEMBL2095188 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | IC50 | = | 62.0 | nM | 7.21 | Inhibitory activity towards Sigma opioid receptor type 1 | 10508425 |
| Protein cereblon | Ki | = | 43000.0 | nM | 4.37 | Binding affinity to CRBN (unknown origin) assessed as inhibition constant by FRE... | 36821822 |
| Glycogen synthase kinase-3 | IC50 | = | 100000.0 | nM | 4.0 | Inhibition of rabbit GSK3 | 16279768 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22077389 | 10.1021/jm201243p | Unchecked | 3 |
| 33488967 | 10.1021/acsmedchemlett.0c00440 | Protein cereblon | 2 |
| 38484804 | 10.1016/j.bmcl.2024.129701 | MRC5 | 2 |
| 10508425 | 10.1021/jm990174v | Sigma non-opioid intracellular receptor 1 | 1 |
| 16279768 | 10.1021/jm040895g | Glycogen synthase kinase-3 | 1 |
| 18834112 | 10.1021/jm800656v | Amine oxidase [flavin-containing] A | 1 |
| 18834112 | 10.1021/jm800656v | Amine oxidase [flavin-containing] B | 1 |
| 22077389 | 10.1021/jm201243p | Prothrombin | 1 |
| 32420743 | 10.1021/acs.jmedchem.0c00120 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 1 |
| 36105338 | 10.1021/acsmedchemlett.2c00256 | Glutaminyl-peptide cyclotransferase | 1 |
| 36821822 | 10.1021/acs.jmedchem.2c01882 | Protein cereblon | 1 |
| 38484804 | 10.1016/j.bmcl.2024.129701 | Plasmodium falciparum | 1 |
Data from ChEMBL 36 via Core Engine