Compound Detail
CHEMBL26241
KRM-7777 Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL26241 |
| Name | KRM-7777 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VNCNRIGKOMHMLM-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
236.3
MW (Da)
1.14
ALogP
5
HBA
0
HBD
44.0
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 CHEMBL2095188 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 5.16 | 5.155 | 7000.0 | 2 |
| Protein kinase C alpha type CHEMBL299 | IC50 | 4.86 | 4.86 | 13800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta | IC50 | = | 7000.0 | nM | 5.16 | Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta | 11881998 |
| Glycogen synthase kinase-3 | IC50 | = | 7000.0 | nM | 5.16 | Inhibition of rabbit GSK3 | 16279768 |
| Glycogen synthase kinase-3 beta | IC50 | = | 7149.0 | nM | 5.15 | Inhibition of GSK3-beta by Z'-LYTE kinase assay | 19081248 |
| Protein kinase C alpha type | IC50 | = | 13800.0 | nM | 4.86 | Inhibition of PKCalpha | 19081248 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19081248 | 10.1016/j.bmcl.2008.10.120 | Glycogen synthase kinase-3 beta | 2 |
| 19081248 | 10.1016/j.bmcl.2008.10.120 | Unchecked | 2 |
| 19081248 | 10.1016/j.bmcl.2008.10.120 | Protein kinase C alpha type | 2 |
| 11881998 | 10.1021/jm011020u | Glycogen synthase kinase-3 beta | 1 |
| 16279768 | 10.1021/jm040895g | Glycogen synthase kinase-3 | 1 |
| 19081248 | 10.1016/j.bmcl.2008.10.120 | Cyclin-dependent kinase 1 | 1 |
| 21757349 | 10.1016/j.bmcl.2011.06.027 | MV4-11 | 1 |
| 21757349 | 10.1016/j.bmcl.2011.06.027 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine