Compound Detail
CHEMBL3898745
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Basic Information
| ChEMBL ID | CHEMBL3898745 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IJQTXEGGUYZYPT-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
483.1
MW (Da)
5.04
ALogP
5
HBA
2
HBD
88.9
PSA (Ų)
0.54
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B CHEMBL275 | IC50 | 8.77 | 8.77 | 1.7 | 1 |
| Unchecked CHEMBL612545 | IC50 | 8.43 | 8.43 | 3.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4B | IC50 | = | 1.7 | nM | 8.77 | Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydroly... | 27933955 |
| Unchecked | IC50 | = | 3.7 | nM | 8.43 | Inhibition of PDE4 in PBMC (unknown origin) assessed as reduction in LPS-induced... | 27933955 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27933955 | 10.1021/acs.jmedchem.6b00829 | Unchecked | 2 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | ADMET | 2 |
| 27933955 | 10.1021/acs.jmedchem.6b00829 | 3',5'-cyclic-AMP phosphodiesterase 4B | 1 |
Data from ChEMBL 36 via Core Engine