Compound Detail
CHEMBL3910011
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Basic Information
| ChEMBL ID | CHEMBL3910011 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TUMHUJUTBSNGPC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
409.5
MW (Da)
5.09
ALogP
3
HBA
1
HBD
54.9
PSA (Ų)
0.45
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein-serine O-palmitoleoyltransferase porcupine CHEMBL1255164 | IC50 | 8.19 | 8.115 | 6.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein-serine O-palmitoleoyltransferase porcupine | IC50 | = | 6.5 | nM | 8.19 | Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells ass... | 29499483 |
| Protein-serine O-palmitoleoyltransferase porcupine | IC50 | = | 9.2 | nM | 8.04 | Inhibition of porcupine in mouse L Wnt3A cells co-cultured with HEK293 cells aft... | 27692509 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27692509 | 10.1016/j.bmc.2016.09.041 | Protein-serine O-palmitoleoyltransferase porcupine | 1 |
| 29499483 | 10.1016/j.ejmech.2018.02.034 | Protein-serine O-palmitoleoyltransferase porcupine | 1 |
Data from ChEMBL 36 via Core Engine