Compound Detail
CHEMBL3912251
ONO-8539 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL3912251 |
| Name | ONO-8539 |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ALLLQQUASFFEKP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
1
Known Names
2
Indications
1
Mechanisms
Molecular Properties
500.6
MW (Da)
5.07
ALogP
6
HBA
1
HBD
96.8
PSA (Ų)
0.44
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Prostanoid EP1 receptor antagonist | ANTAGONIST | Prostaglandin E2 receptor EP1 subtype | ✓ | ✓ |
Indications
Urinary Bladder, Overactive Gastroesophageal Reflux
Activity Summary
IC50 1 meas. best 8.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP1 subtype CHEMBL2181 | IC50 | 8.16 | 8.16 | 6.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP1 subtype | IC50 | = | 6.9 | nM | 8.16 | Inhibition Assay: The cells expressing mouse EP1 receptor were seeded at 104 cel... | - |
Data from ChEMBL 36 via Core Engine