Compound Detail
CHEMBL3919905
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Basic Information
| ChEMBL ID | CHEMBL3919905 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SMKSRBHENMGVPF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
302.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.65
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.65 | 7.65 | 22.5 | 1 |
| Methionine aminopeptidase 2 CHEMBL3922 | IC50 | 5.12 | 5.12 | 7570.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 22.5 | nM | 7.65 | Inhibition of wild type Candida albicans Fructose-1,6-Bisphosphate Aldolase tran... | 35099959 |
| Methionine aminopeptidase 2 | IC50 | = | 7570.0 | nM | 5.12 | Non-covalent/mixed type inhibition of recombinant human MetAP2 using Met-AMC as ... | 27692546 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 35099959 | 10.1021/acs.jmedchem.1c02102 | Candida albicans | 4 |
| 27692546 | 10.1016/j.bmcl.2016.09.050 | Aminopeptidase N | 2 |
| 27692546 | 10.1016/j.bmcl.2016.09.050 | Leucine aminopeptidase | 1 |
| 27692546 | 10.1016/j.bmcl.2016.09.050 | Methionine aminopeptidase 2 | 1 |
| 35099959 | 10.1021/acs.jmedchem.1c02102 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine