Compound Detail
CHEMBL3929647
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3929647 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WFQLDXGNAYZMLS-UHFFFAOYSA-N |
2
Targets
7
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
457.5
MW (Da)
2.34
ALogP
10
HBA
2
HBD
109.7
PSA (Ų)
0.47
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 7.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK CHEMBL2599 | IC50 | 7.36 | 7.36 | 44.0 | 6 |
| CD63 antigen CHEMBL3713303 | IC50 | 6.8 | 6.8 | 157.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase SYK | IC50 | = | 44.0 | nM | 7.36 | High Throughput Syk Biochemical Assay: Syk activity was measured using KinEASE (... | - |
| Tyrosine-protein kinase SYK | IC50 | = | 44.0 | nM | 7.36 | Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Immunoassay: Syk ... | - |
| Tyrosine-protein kinase SYK | IC50 | = | 44.0 | nM | 7.36 | Biochemical Assay: Syk activity was measured using KinEASE (Cisbio), a time-reso... | - |
| Tyrosine-protein kinase SYK | IC50 | = | 44.0 | nM | 7.36 | High Throughput Syk Biochemical Assay: Syk activity was measured using KinEASE (... | - |
| Tyrosine-protein kinase SYK | IC50 | = | 44.0 | nM | 7.36 | High Throughput Biochemical Assay: Syk activity was measured using KinEASE (Cisb... | - |
| Tyrosine-protein kinase SYK | IC50 | = | 44.0 | nM | 7.36 | High Throughput Syk Biochemical Assay: Syk activity was measured using KinEASE (... | - |
| CD63 antigen | IC50 | = | 157.0 | nM | 6.8 | High Throughput Syk Biochemical Assay: Syk activity was measured using KinEASE (... | - |
Data from ChEMBL 36 via Core Engine