Compound Detail
CHEMBL393258
LASIODIPLODIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL393258 |
| Name | LASIODIPLODIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OKWRDLQBKAOJNC-LBPRGKRZSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
12
Publications
0
Known Names
Molecular Properties
292.4
MW (Da)
3.84
ALogP
4
HBA
1
HBD
55.8
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 4.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| U-937 CHEMBL612794 | IC50 | 4.7 | 4.5633 | 20000.0 | 3 |
| Spinacia oleracea CHEMBL612824 | IC50 | 4.45 | 4.45 | 35600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| U-937 | IC50 | = | 20000.0 | nM | 4.7 | Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay | 17158054 |
| U-937 | IC50 | = | 28000.0 | nM | 4.55 | Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay | 17158054 |
| Spinacia oleracea | IC50 | = | 35600.0 | nM | 4.45 | Inhibition of ATP sythesis in freshly lysed Spinacia oleracea (spinach) chloropl... | 17432876 |
| U-937 | IC50 | = | 36000.0 | nM | 4.44 | Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay | 17158054 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17432876 | 10.1021/jf070082b | Unchecked | 11 |
| 17432876 | 10.1021/jf070082b | Chloroplast coupling factor 1 | 9 |
| 17432876 | 10.1021/jf070082b | Spinacia oleracea | 7 |
| 27592135 | 10.1016/j.bmcl.2016.08.019 | NON-PROTEIN TARGET | 5 |
| 17158054 | 10.1016/j.bmc.2006.09.024 | U-937 | 3 |
| 16781152 | 10.1016/j.bmcl.2006.05.081 | Fusarium oxysporum | 1 |
| 16781152 | 10.1016/j.bmcl.2006.05.081 | Candida albicans | 1 |
| 16781152 | 10.1016/j.bmcl.2006.05.081 | Salmonella enteritidis | 1 |
| 16781152 | 10.1016/j.bmcl.2006.05.081 | Escherichia coli | 1 |
| 16781152 | 10.1016/j.bmcl.2006.05.081 | Bacillus subtilis | 1 |
| 16781152 | 10.1016/j.bmcl.2006.05.081 | Staphylococcus aureus | 1 |
| 27592135 | 10.1016/j.bmcl.2016.08.019 | BV-2 | 1 |
Data from ChEMBL 36 via Core Engine