Assay Detail
Functional
CHEMBL885741
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-937 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 4.58 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.17 |
| CHEMBL240545 | ROTENOLONE | — | 1 | 5.44 |
| CHEMBL429023 | ROTENONE | — | 1 | 4.89 |
| CHEMBL393223 | DERRONE | — | 1 | 4.58 |
| CHEMBL393222 | WIGHTEONE | — | 1 | 4.55 |
| CHEMBL240930 | — | — | 1 | 4.54 |
| CHEMBL241806 | TEPHROSIN | — | 1 | 4.52 |
| CHEMBL238628 | ALPINUMISOFLAVONE | — | 1 | 4.46 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.44 |
| CHEMBL393258 | LASIODIPLODIN | — | 1 | 4.44 |
| CHEMBL241569 | ERYCEBENIN E | — | 1 | 4.43 |
| CHEMBL397828 | — | — | 1 | 4.41 |
| CHEMBL393417 | DEGUELIN | — | 1 | 4.38 |
| CHEMBL241817 | ERYCIBENIN A | — | 1 | 4.34 |
| CHEMBL241608 | CALYCOSIN | — | 1 | 4.31 |
| CHEMBL242341 | FORMONONETIN | 2.0 | 1 | 4.30 |
| CHEMBL241402 | 3'-O-METHYLOROBOL | — | 1 | 4.17 |
| CHEMBL241609 | OROBOL | — | 1 | 4.14 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | - |
| CHEMBL240929 | ERYCIBENIN C | — | 1 | - |
| CHEMBL427693 | ERYCIBENIN B | — | 1 | - |
| CHEMBL391981 | ERYCIBENIN F | — | 1 | - |
| CHEMBL430186 | — | — | 1 | - |
| CHEMBL273891 | — | — | 1 | - |
| CHEMBL8996 | ERIODICTYOL | — | 1 | - |
| CHEMBL241571 | ERYCIBENIN D | — | 1 | - |
| CHEMBL238823 | MEDICARPIN | — | 1 | - |
| CHEMBL396671 | HOMOPTEROCARPIN | — | 1 | - |
| CHEMBL334918 | MAACKIAIN | — | 1 | - |
| CHEMBL242128 | PTEROCARPIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL240545 | ROTENOLONE | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL429023 | ROTENONE | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL393223 | DERRONE | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL393222 | WIGHTEONE | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL240930 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL241806 | TEPHROSIN | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL238628 | ALPINUMISOFLAVONE | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL393258 | LASIODIPLODIN | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL241569 | ERYCEBENIN E | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL397828 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL393417 | DEGUELIN | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL241817 | ERYCIBENIN A | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL241608 | CALYCOSIN | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL242341 | FORMONONETIN | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL241402 | 3'-O-METHYLOROBOL | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL241609 | OROBOL | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL44 | GENISTEIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL240929 | ERYCIBENIN C | IC50 | > | 100000.0 | nM | - |
| CHEMBL427693 | ERYCIBENIN B | IC50 | > | 100000.0 | nM | - |
| CHEMBL391981 | ERYCIBENIN F | IC50 | > | 100000.0 | nM | - |
| CHEMBL430186 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL273891 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8996 | ERIODICTYOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL241571 | ERYCIBENIN D | IC50 | > | 100000.0 | nM | - |
| CHEMBL238823 | MEDICARPIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL396671 | HOMOPTEROCARPIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL334918 | MAACKIAIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL242128 | PTEROCARPIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL239005 | SECUNDIFLOROL I | IC50 | > | 100000.0 | nM | - |
| CHEMBL391520 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL240715 | — | IC50 | > | 100000.0 | nM | - |