Compound Detail
CHEMBL393727
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Basic Information
| ChEMBL ID | CHEMBL393727 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OGVWKHPUKXDHAB-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
402.4
MW (Da)
3.68
ALogP
5
HBA
1
HBD
73.4
PSA (Ų)
0.68
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Coagulation factor X CHEMBL244 | Ki | 5.8 | 5.8 | 1584.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Coagulation factor X | Ki | = | 1600.0 | nM | 5.8 | Binding affinity to human F10a | 17914785 |
| Coagulation factor X | Ki | = | 1584.89 | nM | 5.8 | Inhibition of human factor 10a | 21443196 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17914785 | 10.1021/jm070245n | Coagulation factor X | 1 |
| 17914785 | 10.1021/jm070245n | Prothrombin | 1 |
| 17914785 | 10.1021/jm070245n | Plasma | 1 |
| 21443196 | 10.1021/jm200026b | Coagulation factor X | 1 |
Data from ChEMBL 36 via Core Engine