Compound Detail
CHEMBL3948664
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
C=CC(=O)Nc1cc(N2CCN(CC)CC2)ccc1Nc1cc(N(C)C(=O)Nc2cc(OC)cc(OC)c2Cl)ncn1
Basic Information
| ChEMBL ID | CHEMBL3948664 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VIXYFBBPPGAXIS-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
595.1
MW (Da)
4.83
ALogP
9
HBA
3
HBD
124.2
PSA (Ų)
0.28
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.7 | 8.7 | 2.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 4 | IC50 | = | 2.0 | nM | 8.7 | Kinase HotSpotâ¿¢ Assay: Compounds were profiled for FGFR inhibition activity at... | - |
| Fibroblast growth factor receptor 4 | IC50 | = | 2.0 | nM | 8.7 | Binding Assay: Purified, recombinant FGFR4 was pre-incubated with 10 μM compound... | - |
| Fibroblast growth factor receptor 4 | IC50 | = | 2.0 | nM | 8.7 | Kinase Activity Inhibition Assay: Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR... | - |
| Fibroblast growth factor receptor 4 | IC50 | = | 2.0 | nM | 8.7 | Inhibition Activity Assay: Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM... | - |
Data from ChEMBL 36 via Core Engine