Compound Detail
CHEMBL3948698
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Basic Information
| ChEMBL ID | CHEMBL3948698 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MHJHIWOUBFMLDH-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3924872 |
| Active Moiety | CHEMBL3924872 |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
445.5
MW (Da)
3.96
ALogP
8
HBA
1
HBD
85.5
PSA (Ų)
0.42
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 7.43 | 7.43 | 37.1 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.77 | 6.77 | 169.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 37.15 | nM | 7.43 | Inhibition of TEL-fused FGFR3 (unknown origin) transfected in mouse BA/F3 cells ... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 169.82 | nM | 6.77 | Inhibition of recombinant human N-terminal His6-tagged VEGFR2 (790 end residues)... | - |
Data from ChEMBL 36 via Core Engine