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Assay Detail

CHEMBL3880352

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of TEL-fused FGFR3 (unknown origin) transfected in mouse BA/F3 cells assessed as decrease in cell proliferation in presence of mouse IL3 after 72 hrs by Alamar blue assay
ChEMBL ↗
56
Total Activities
56
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BaF3
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fibroblast growth factor receptor 3 (CHEMBL2742) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazolyl quinoxaline kinase inhibitors
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 56 8.20 9.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3942763 — — 1 9.41
CHEMBL3961923 — — 1 9.34
CHEMBL3984039 — — 1 9.24
CHEMBL3962736 — — 1 9.24
CHEMBL3969381 — — 1 9.23
CHEMBL3922586 — — 1 9.17
CHEMBL3958312 — — 1 9.17
CHEMBL3934596 — — 1 9.10
CHEMBL3939439 — — 1 9.05
CHEMBL3893398 — — 1 9.05
CHEMBL3907195 — — 1 9.04
CHEMBL3944340 — — 1 9.04
CHEMBL3898322 — — 1 8.96
CHEMBL3931421 — — 1 8.96
CHEMBL3955800 — — 1 8.96
CHEMBL3954671 — — 1 8.96
CHEMBL3896104 — — 1 8.92
CHEMBL3932112 — — 1 8.89
CHEMBL3978453 — — 1 8.89
CHEMBL3922285 — — 1 8.77
CHEMBL3903768 — — 1 8.66
CHEMBL3974693 — — 1 8.66
CHEMBL3959345 — — 1 8.60
CHEMBL3925286 — — 1 8.60
CHEMBL3890896 — — 1 8.57
CHEMBL3951316 — — 1 8.43
CHEMBL3985678 — — 1 8.43
CHEMBL3925008 — — 1 8.42
CHEMBL3967011 — — 1 8.38
CHEMBL3915533 — — 1 8.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3942763 — IC50 = 0.389 nM 9.41
CHEMBL3961923 — IC50 = 0.4571 nM 9.34
CHEMBL3962736 — IC50 = 0.5754 nM 9.24
CHEMBL3984039 — IC50 = 0.5754 nM 9.24
CHEMBL3969381 — IC50 = 0.5888 nM 9.23
CHEMBL3922586 — IC50 = 0.6761 nM 9.17
CHEMBL3958312 — IC50 = 0.6761 nM 9.17
CHEMBL3934596 — IC50 = 0.7943 nM 9.10
CHEMBL3939439 — IC50 = 0.8913 nM 9.05
CHEMBL3893398 — IC50 = 0.8913 nM 9.05
CHEMBL3907195 — IC50 = 0.912 nM 9.04
CHEMBL3944340 — IC50 = 0.912 nM 9.04
CHEMBL3931421 — IC50 = 1.096 nM 8.96
CHEMBL3898322 — IC50 = 1.096 nM 8.96
CHEMBL3955800 — IC50 = 1.096 nM 8.96
CHEMBL3954671 — IC50 = 1.096 nM 8.96
CHEMBL3896104 — IC50 = 1.202 nM 8.92
CHEMBL3932112 — IC50 = 1.288 nM 8.89
CHEMBL3978453 — IC50 = 1.288 nM 8.89
CHEMBL3922285 — IC50 = 1.698 nM 8.77
CHEMBL3903768 — IC50 = 2.188 nM 8.66
CHEMBL3974693 — IC50 = 2.188 nM 8.66
CHEMBL3959345 — IC50 = 2.512 nM 8.60
CHEMBL3925286 — IC50 = 2.512 nM 8.60
CHEMBL3890896 — IC50 = 2.692 nM 8.57
CHEMBL3951316 — IC50 = 3.715 nM 8.43
CHEMBL3985678 — IC50 = 3.715 nM 8.43
CHEMBL3925008 — IC50 = 3.802 nM 8.42
CHEMBL3967011 — IC50 = 4.169 nM 8.38
CHEMBL3915533 — IC50 = 6.166 nM 8.21
CHEMBL3927947 — IC50 = 6.31 nM 8.20
CHEMBL3971277 — IC50 = 6.31 nM 8.20
CHEMBL3967645 — IC50 = 8.71 nM 8.06
CHEMBL3919730 — IC50 = 8.71 nM 8.06
CHEMBL3901357 — IC50 = 10.96 nM 7.96
CHEMBL3986607 — IC50 = 10.96 nM 7.96
CHEMBL3985332 — IC50 = 12.02 nM 7.92
CHEMBL3956571 — IC50 = 12.02 nM 7.92
CHEMBL3922418 — IC50 = 12.88 nM 7.89
CHEMBL3897858 — IC50 = 19.95 nM 7.70
CHEMBL3957643 — IC50 = 21.88 nM 7.66
CHEMBL3928646 — IC50 = 26.3 nM 7.58
CHEMBL3935912 — IC50 = 26.3 nM 7.58
CHEMBL3924872 — IC50 = 37.15 nM 7.43
CHEMBL3948698 — IC50 = 37.15 nM 7.43
CHEMBL3968361 — IC50 = 48.98 nM 7.31
CHEMBL3890126 — IC50 = 53.7 nM 7.27
CHEMBL3981706 — IC50 = 120.23 nM 6.92
CHEMBL3938610 — IC50 = 128.82 nM 6.89
CHEMBL3969061 — IC50 = 141.25 nM 6.85