Compound Detail
CHEMBL3896104
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Basic Information
| ChEMBL ID | CHEMBL3896104 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FIQVXPKIJWECRH-UHFFFAOYSA-N |
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
496.6
MW (Da)
3.12
ALogP
9
HBA
1
HBD
111.5
PSA (Ų)
0.33
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.92 | 8.225 | 1.2 | 2 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.92 | 7.185 | 12.0 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.43 | 7.43 | 37.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 1.202 | nM | 8.92 | Inhibition of TEL-fused FGFR3 (unknown origin) transfected in mouse BA/F3 cells ... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 12.02 | nM | 7.92 | Inhibition of recombinant human N-terminal His6-tagged VEGFR2 (790 end residues)... | - |
| Fibroblast growth factor receptor 3 | IC50 | = | 29.51 | nM | 7.53 | Inhibition of FGFR3 (unknown origin) transfected in mouse BA/F3 cells assessed a... | - |
| Fibroblast growth factor receptor 1 | IC50 | = | 37.15 | nM | 7.43 | Inhibition of FGFR1 (unknown origin) transfected in mouse BA/F3 cells assessed a... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 354.81 | nM | 6.45 | Inhibition of VEGFR2 (unknown origin) transfected in mouse BA/F3 cells assessed ... | - |
Data from ChEMBL 36 via Core Engine