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Assay Detail

CHEMBL3880346

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Binding
Inhibition of VEGFR2 (unknown origin) transfected in mouse BA/F3 cells assessed as decrease in cell proliferation in absence of mouse IL3 after 24 hrs by Alamar blue assay
ChEMBL ↗
647
Total Activities
647
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BaF3
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazolyl quinoxaline kinase inhibitors
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 647 5.59 7.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3954396 — — 1 7.61
CHEMBL3933000 — — 1 7.05
CHEMBL3986068 — — 1 6.96
CHEMBL3901420 — — 1 6.94
CHEMBL3903973 — — 1 6.87
CHEMBL3921618 — — 1 6.75
CHEMBL3907314 — — 1 6.75
CHEMBL3919173 — — 1 6.69
CHEMBL3894762 — — 1 6.66
CHEMBL3918092 — — 1 6.65
CHEMBL3984039 — — 1 6.65
CHEMBL3955563 — — 1 6.64
CHEMBL3945264 — — 1 6.62
CHEMBL3892529 — — 1 6.61
CHEMBL3913492 — — 1 6.57
CHEMBL3919479 — — 1 6.51
CHEMBL3896104 — — 1 6.45
CHEMBL3890607 — — 1 6.43
CHEMBL3958209 — — 1 6.42
CHEMBL3892135 — — 1 6.40
CHEMBL3947361 — — 1 6.40
CHEMBL3975447 — — 1 6.39
CHEMBL3910444 — — 1 6.38
CHEMBL3893398 — — 1 6.35
CHEMBL3943860 — — 1 6.35
CHEMBL3933707 — — 1 6.34
CHEMBL3905048 — — 1 6.34
CHEMBL3979328 — — 1 6.33
CHEMBL3978754 — — 1 6.33
CHEMBL3970430 — — 1 6.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3954396 — IC50 = 24.55 nM 7.61
CHEMBL3933000 — IC50 = 89.13 nM 7.05
CHEMBL3986068 — IC50 = 109.65 nM 6.96
CHEMBL3901420 — IC50 = 114.82 nM 6.94
CHEMBL3903973 — IC50 = 134.9 nM 6.87
CHEMBL3921618 — IC50 = 177.83 nM 6.75
CHEMBL3907314 — IC50 = 177.83 nM 6.75
CHEMBL3919173 — IC50 = 204.17 nM 6.69
CHEMBL3894762 — IC50 = 218.78 nM 6.66
CHEMBL3984039 — IC50 = 223.87 nM 6.65
CHEMBL3918092 — IC50 = 223.87 nM 6.65
CHEMBL3955563 — IC50 = 229.09 nM 6.64
CHEMBL3945264 — IC50 = 239.88 nM 6.62
CHEMBL3892529 — IC50 = 245.47 nM 6.61
CHEMBL3913492 — IC50 = 269.15 nM 6.57
CHEMBL3919479 — IC50 = 309.03 nM 6.51
CHEMBL3896104 — IC50 = 354.81 nM 6.45
CHEMBL3890607 — IC50 = 371.54 nM 6.43
CHEMBL3958209 — IC50 = 380.19 nM 6.42
CHEMBL3947361 — IC50 = 398.11 nM 6.40
CHEMBL3892135 — IC50 = 398.11 nM 6.40
CHEMBL3975447 — IC50 = 407.38 nM 6.39
CHEMBL3910444 — IC50 = 416.87 nM 6.38
CHEMBL3893398 — IC50 = 446.68 nM 6.35
CHEMBL3943860 — IC50 = 446.68 nM 6.35
CHEMBL3933707 — IC50 = 457.09 nM 6.34
CHEMBL3905048 — IC50 = 457.09 nM 6.34
CHEMBL3978754 — IC50 = 467.74 nM 6.33
CHEMBL3979328 — IC50 = 467.74 nM 6.33
CHEMBL3970430 — IC50 = 478.63 nM 6.32
CHEMBL3964574 — IC50 = 478.63 nM 6.32
CHEMBL3944610 — IC50 = 489.78 nM 6.31
CHEMBL3893786 — IC50 = 501.19 nM 6.30
CHEMBL3944438 — IC50 = 512.86 nM 6.29
CHEMBL3932756 — IC50 = 549.54 nM 6.26
CHEMBL3928261 — IC50 = 575.44 nM 6.24
CHEMBL3968499 — IC50 = 575.44 nM 6.24
CHEMBL3960877 — IC50 = 602.56 nM 6.22
CHEMBL3935597 — IC50 = 630.96 nM 6.20
CHEMBL3983529 — IC50 = 645.65 nM 6.19
CHEMBL3936765 — IC50 = 676.08 nM 6.17
CHEMBL3944320 — IC50 = 691.83 nM 6.16
CHEMBL3983918 — IC50 = 741.31 nM 6.13
CHEMBL3985222 — IC50 = 758.58 nM 6.12
CHEMBL3917908 — IC50 = 794.33 nM 6.10
CHEMBL3932363 — IC50 = 812.83 nM 6.09
CHEMBL3912569 — IC50 = 812.83 nM 6.09
CHEMBL3949132 — IC50 = 812.83 nM 6.09
CHEMBL3947189 — IC50 = 812.83 nM 6.09
CHEMBL3896142 — IC50 = 831.76 nM 6.08