Compound Detail
CHEMBL3892529
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
COc1cc(OC)c(F)c(N(CCCNCC(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1F
Basic Information
| ChEMBL ID | CHEMBL3892529 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GLLVJFAKHOOPKT-UHFFFAOYSA-N |
6
Targets
7
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
536.5
MW (Da)
5.01
ALogP
8
HBA
1
HBD
77.3
PSA (Ų)
0.23
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 8.86
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.86 | 8.86 | 1.4 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.68 | 8.68 | 2.1 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.56 | 8.56 | 2.8 | 1 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.53 | 8.53 | 3.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.85 | 7.23 | 14.1 | 2 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 4.99 | 4.99 | 10232.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine