Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3880348

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of FLT3 (unknown origin) transfected in mouse BA/F3 cells assessed as decrease in cell proliferation in absence of mouse IL3 after 24 hrs by Alamar blue assay
ChEMBL ↗
647
Total Activities
647
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BaF3
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazolyl quinoxaline kinase inhibitors
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 647 5.25 6.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3890896 — — 1 6.84
CHEMBL3965614 — — 1 6.12
CHEMBL3979972 — — 1 6.12
CHEMBL3905633 — — 1 6.07
CHEMBL3969824 — — 1 5.98
CHEMBL3982399 — — 1 5.98
CHEMBL3983387 — — 1 5.93
CHEMBL3893642 — — 1 5.85
CHEMBL3954396 — — 1 5.85
CHEMBL3891525 — — 1 5.81
CHEMBL3902961 — — 1 5.77
CHEMBL3947740 — — 1 5.71
CHEMBL3901420 — — 1 5.68
CHEMBL3964762 — — 1 5.67
CHEMBL3964043 — — 1 5.66
CHEMBL3978349 — — 1 5.65
CHEMBL3986725 — — 1 5.60
CHEMBL3892776 — — 1 5.53
CHEMBL3959787 — — 1 5.50
CHEMBL3903973 — — 1 5.50
CHEMBL3906253 — — 1 5.50
CHEMBL3978754 — — 1 5.48
CHEMBL3946938 — — 1 5.47
CHEMBL3967761 — — 1 5.45
CHEMBL3951360 — — 1 5.44
CHEMBL3980232 — — 1 5.43
CHEMBL3927140 — — 1 5.43
CHEMBL3918800 — — 1 5.42
CHEMBL3964931 — — 1 5.42
CHEMBL3917908 — — 1 5.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3890896 — IC50 = 144.54 nM 6.84
CHEMBL3979972 — IC50 = 758.58 nM 6.12
CHEMBL3965614 — IC50 = 758.58 nM 6.12
CHEMBL3905633 — IC50 = 851.14 nM 6.07
CHEMBL3969824 — IC50 = 1047.13 nM 5.98
CHEMBL3982399 — IC50 = 1047.13 nM 5.98
CHEMBL3983387 — IC50 = 1174.9 nM 5.93
CHEMBL3893642 — IC50 = 1412.54 nM 5.85
CHEMBL3954396 — IC50 = 1412.54 nM 5.85
CHEMBL3891525 — IC50 = 1548.82 nM 5.81
CHEMBL3902961 — IC50 = 1698.24 nM 5.77
CHEMBL3947740 — IC50 = 1949.84 nM 5.71
CHEMBL3901420 — IC50 = 2089.3 nM 5.68
CHEMBL3964762 — IC50 = 2137.96 nM 5.67
CHEMBL3964043 — IC50 = 2187.76 nM 5.66
CHEMBL3978349 — IC50 = 2238.72 nM 5.65
CHEMBL3986725 — IC50 = 2511.89 nM 5.60
CHEMBL3892776 — IC50 = 2951.21 nM 5.53
CHEMBL3959787 — IC50 = 3162.28 nM 5.50
CHEMBL3903973 — IC50 = 3162.28 nM 5.50
CHEMBL3906253 — IC50 = 3162.28 nM 5.50
CHEMBL3978754 — IC50 = 3311.31 nM 5.48
CHEMBL3946938 — IC50 = 3388.44 nM 5.47
CHEMBL3967761 — IC50 = 3548.13 nM 5.45
CHEMBL3951360 — IC50 = 3630.78 nM 5.44
CHEMBL3980232 — IC50 = 3715.35 nM 5.43
CHEMBL3927140 — IC50 = 3715.35 nM 5.43
CHEMBL3918800 — IC50 = 3801.89 nM 5.42
CHEMBL3964931 — IC50 = 3801.89 nM 5.42
CHEMBL3917908 — IC50 = 3890.45 nM 5.41
CHEMBL3904441 — IC50 = 4265.8 nM 5.37
CHEMBL3956571 — IC50 = 4265.8 nM 5.37
CHEMBL3896249 — IC50 = 4265.8 nM 5.37
CHEMBL3933442 — IC50 = 4365.16 nM 5.36
CHEMBL3902434 — IC50 = 4466.84 nM 5.35
CHEMBL3950262 — IC50 = 4466.84 nM 5.35
CHEMBL3950292 — IC50 = 4570.88 nM 5.34
CHEMBL3979328 — IC50 = 4677.35 nM 5.33
CHEMBL3945658 — IC50 = 4677.35 nM 5.33
CHEMBL3943933 — IC50 = 4677.35 nM 5.33
CHEMBL3892155 — IC50 = 4786.3 nM 5.32
CHEMBL3977708 — IC50 = 4786.3 nM 5.32
CHEMBL3968009 — IC50 = 4786.3 nM 5.32
CHEMBL3976275 — IC50 = 4786.3 nM 5.32
CHEMBL3936765 — IC50 = 4786.3 nM 5.32
CHEMBL3943917 — IC50 = 4897.79 nM 5.31
CHEMBL3933000 — IC50 = 4897.79 nM 5.31
CHEMBL3898926 — IC50 = 4897.79 nM 5.31
CHEMBL3935838 — IC50 = 4897.79 nM 5.31
CHEMBL3970423 — IC50 = 5011.87 nM 5.30