Compound Detail
CHEMBL3959787
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
COc1cc(OC)cc(N(CC#Cc2cc(OC)ncn2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1
Basic Information
| ChEMBL ID | CHEMBL3959787 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SDIZOFZVSQJIHJ-UHFFFAOYSA-N |
6
Targets
12
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
507.6
MW (Da)
4.04
ALogP
10
HBA
0
HBD
100.3
PSA (Ų)
0.30
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 12 meas. best 7.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 7.32 | 6.54 | 47.9 | 3 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.15 | 6.6033 | 70.8 | 3 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 7.05 | 7.05 | 89.1 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 6.64 | 6.64 | 229.1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.5 | 5.45 | 3162.3 | 2 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.41 | 5.395 | 3890.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine