Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3880337

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human FGFR1 using Btn-Flt3 as substrate after 60 mins by TR-FRET assay
ChEMBL ↗
623
Total Activities
623
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fibroblast growth factor receptor 1 (CHEMBL3650) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazolyl quinoxaline kinase inhibitors
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 623 8.15 9.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3980069 — — 1 9.44
CHEMBL3907314 — — 1 9.35
CHEMBL3918638 — — 1 9.34
CHEMBL3921618 — — 1 9.29
CHEMBL3904674 — — 1 9.26
CHEMBL3919173 — — 1 9.25
CHEMBL3906894 — — 1 9.23
CHEMBL3979490 — — 1 9.21
CHEMBL3966748 — — 1 9.21
CHEMBL3979013 — — 1 9.21
CHEMBL3896249 — — 1 9.17
CHEMBL3919730 — — 1 9.14
CHEMBL3918092 — — 1 9.12
CHEMBL3901119 — — 1 9.12
CHEMBL3983918 — — 1 9.12
CHEMBL3945159 — — 1 9.11
CHEMBL3921817 — — 1 9.11
CHEMBL3921197 — — 1 9.08
CHEMBL3931421 — — 1 9.07
CHEMBL3912569 — — 1 9.06
CHEMBL3919709 — — 1 9.06
CHEMBL3942763 — — 1 9.05
CHEMBL3975791 — — 1 9.04
CHEMBL3964096 — — 1 9.04
CHEMBL3935597 — — 1 9.03
CHEMBL3968499 — — 1 9.02
CHEMBL3927875 — — 1 9.01
CHEMBL3975447 — — 1 9.01
CHEMBL3937972 — — 1 9.01
CHEMBL3936672 — — 1 9.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3980069 — IC50 = 0.3631 nM 9.44
CHEMBL3907314 — IC50 = 0.4467 nM 9.35
CHEMBL3918638 — IC50 = 0.4571 nM 9.34
CHEMBL3921618 — IC50 = 0.5129 nM 9.29
CHEMBL3904674 — IC50 = 0.5495 nM 9.26
CHEMBL3919173 — IC50 = 0.5623 nM 9.25
CHEMBL3906894 — IC50 = 0.5888 nM 9.23
CHEMBL3966748 — IC50 = 0.6166 nM 9.21
CHEMBL3979490 — IC50 = 0.6166 nM 9.21
CHEMBL3979013 — IC50 = 0.6166 nM 9.21
CHEMBL3896249 — IC50 = 0.6761 nM 9.17
CHEMBL3919730 — IC50 = 0.7244 nM 9.14
CHEMBL3901119 — IC50 = 0.7586 nM 9.12
CHEMBL3983918 — IC50 = 0.7586 nM 9.12
CHEMBL3918092 — IC50 = 0.7586 nM 9.12
CHEMBL3945159 — IC50 = 0.7762 nM 9.11
CHEMBL3921817 — IC50 = 0.7762 nM 9.11
CHEMBL3921197 — IC50 = 0.8318 nM 9.08
CHEMBL3931421 — IC50 = 0.8511 nM 9.07
CHEMBL3912569 — IC50 = 0.871 nM 9.06
CHEMBL3919709 — IC50 = 0.871 nM 9.06
CHEMBL3942763 — IC50 = 0.8913 nM 9.05
CHEMBL3975791 — IC50 = 0.912 nM 9.04
CHEMBL3964096 — IC50 = 0.912 nM 9.04
CHEMBL3935597 — IC50 = 0.9333 nM 9.03
CHEMBL3968499 — IC50 = 0.955 nM 9.02
CHEMBL3937972 — IC50 = 0.9772 nM 9.01
CHEMBL3975447 — IC50 = 0.9772 nM 9.01
CHEMBL3927875 — IC50 = 0.9772 nM 9.01
CHEMBL3936672 — IC50 = 1.0 nM 9.00
CHEMBL3960877 — IC50 = 1.0 nM 9.00
CHEMBL3942328 — IC50 = 1.023 nM 8.99
CHEMBL3928393 — IC50 = 1.023 nM 8.99
CHEMBL3969446 — IC50 = 1.023 nM 8.99
CHEMBL3964701 — IC50 = 1.047 nM 8.98
CHEMBL3972979 — IC50 = 1.047 nM 8.98
CHEMBL3955563 — IC50 = 1.072 nM 8.97
CHEMBL3985222 — IC50 = 1.072 nM 8.97
CHEMBL3909529 — IC50 = 1.096 nM 8.96
CHEMBL3891892 — IC50 = 1.096 nM 8.96
CHEMBL3951694 — IC50 = 1.096 nM 8.96
CHEMBL3950089 — IC50 = 1.122 nM 8.95
CHEMBL3905485 — IC50 = 1.148 nM 8.94
CHEMBL3921469 — IC50 = 1.175 nM 8.93
CHEMBL3966305 — IC50 = 1.175 nM 8.93
CHEMBL3913322 — IC50 = 1.175 nM 8.93
CHEMBL3980232 — IC50 = 1.175 nM 8.93
CHEMBL3922698 — IC50 = 1.202 nM 8.92
CHEMBL3981418 — IC50 = 1.23 nM 8.91
CHEMBL3943043 — IC50 = 1.23 nM 8.91