Compound Detail
CHEMBL3972979
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CNC(=O)Cn1cc(-c2cnc3ccc(N(CCCN4CCCC4)c4cc(OC)cc(OC)c4)cc3n2)cn1
Basic Information
| ChEMBL ID | CHEMBL3972979 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VZUAVFLTRIZLOD-UHFFFAOYSA-N |
5
Targets
8
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
529.6
MW (Da)
3.88
ALogP
9
HBA
1
HBD
97.6
PSA (Ų)
0.31
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 8 meas. best 8.98
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.98 | 8.24 | 1.0 | 2 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.64 | 8.265 | 2.3 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.54 | 8.54 | 2.9 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.29 | 8.29 | 5.1 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.37 | 6.63 | 42.7 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine