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Assay Detail

CHEMBL3880340

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human FGFR4 using Btn-Flt3 as substrate after 60 mins by TR-FRET assay
ChEMBL ↗
627
Total Activities
627
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fibroblast growth factor receptor 4 (CHEMBL3973) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazolyl quinoxaline kinase inhibitors
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 627 7.56 8.91

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3921618 — — 1 8.91
CHEMBL3928393 — — 1 8.79
CHEMBL3983918 — — 1 8.79
CHEMBL3919173 — — 1 8.78
CHEMBL3907314 — — 1 8.72
CHEMBL3912569 — — 1 8.68
CHEMBL3903973 — — 1 8.67
CHEMBL3964574 — — 1 8.65
CHEMBL3913322 — — 1 8.60
CHEMBL3891892 — — 1 8.58
CHEMBL3892529 — — 1 8.56
CHEMBL3898908 — — 1 8.55
CHEMBL3904674 — — 1 8.54
CHEMBL3906894 — — 1 8.52
CHEMBL3897101 — — 1 8.52
CHEMBL3935825 — — 1 8.52
CHEMBL3918092 — — 1 8.51
CHEMBL3978754 — — 1 8.50
CHEMBL3945373 — — 1 8.49
CHEMBL3911635 — — 1 8.49
CHEMBL3945159 — — 1 8.47
CHEMBL3975447 — — 1 8.46
CHEMBL3935597 — — 1 8.45
CHEMBL3933000 — — 1 8.43
CHEMBL3937972 — — 1 8.43
CHEMBL3968009 — — 1 8.42
CHEMBL3900574 — — 1 8.42
CHEMBL3893786 — — 1 8.42
CHEMBL3958209 — — 1 8.42
CHEMBL3913757 — — 1 8.40

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3921618 — IC50 = 1.23 nM 8.91
CHEMBL3928393 — IC50 = 1.622 nM 8.79
CHEMBL3983918 — IC50 = 1.622 nM 8.79
CHEMBL3919173 — IC50 = 1.66 nM 8.78
CHEMBL3907314 — IC50 = 1.905 nM 8.72
CHEMBL3912569 — IC50 = 2.089 nM 8.68
CHEMBL3903973 — IC50 = 2.138 nM 8.67
CHEMBL3964574 — IC50 = 2.239 nM 8.65
CHEMBL3913322 — IC50 = 2.512 nM 8.60
CHEMBL3891892 — IC50 = 2.63 nM 8.58
CHEMBL3892529 — IC50 = 2.754 nM 8.56
CHEMBL3898908 — IC50 = 2.818 nM 8.55
CHEMBL3904674 — IC50 = 2.884 nM 8.54
CHEMBL3897101 — IC50 = 3.02 nM 8.52
CHEMBL3906894 — IC50 = 3.02 nM 8.52
CHEMBL3935825 — IC50 = 3.02 nM 8.52
CHEMBL3918092 — IC50 = 3.09 nM 8.51
CHEMBL3978754 — IC50 = 3.162 nM 8.50
CHEMBL3945373 — IC50 = 3.236 nM 8.49
CHEMBL3911635 — IC50 = 3.236 nM 8.49
CHEMBL3945159 — IC50 = 3.388 nM 8.47
CHEMBL3975447 — IC50 = 3.467 nM 8.46
CHEMBL3935597 — IC50 = 3.548 nM 8.45
CHEMBL3933000 — IC50 = 3.715 nM 8.43
CHEMBL3937972 — IC50 = 3.715 nM 8.43
CHEMBL3958209 — IC50 = 3.802 nM 8.42
CHEMBL3900574 — IC50 = 3.802 nM 8.42
CHEMBL3893786 — IC50 = 3.802 nM 8.42
CHEMBL3968009 — IC50 = 3.802 nM 8.42
CHEMBL3913757 — IC50 = 3.981 nM 8.40
CHEMBL3936087 — IC50 = 3.981 nM 8.40
CHEMBL3984039 — IC50 = 4.074 nM 8.39
CHEMBL3950910 — IC50 = 4.266 nM 8.37
CHEMBL3968499 — IC50 = 4.266 nM 8.37
CHEMBL3985692 — IC50 = 4.266 nM 8.37
CHEMBL3892776 — IC50 = 4.266 nM 8.37
CHEMBL3926082 — IC50 = 4.365 nM 8.36
CHEMBL3975791 — IC50 = 4.365 nM 8.36
CHEMBL3976275 — IC50 = 4.365 nM 8.36
CHEMBL3922698 — IC50 = 4.467 nM 8.35
CHEMBL3951245 — IC50 = 4.467 nM 8.35
CHEMBL3901119 — IC50 = 4.571 nM 8.34
CHEMBL3902961 — IC50 = 4.677 nM 8.33
CHEMBL3942763 — IC50 = 4.677 nM 8.33
CHEMBL3921457 — IC50 = 4.677 nM 8.33
CHEMBL3980232 — IC50 = 4.677 nM 8.33
CHEMBL3931421 — IC50 = 4.677 nM 8.33
CHEMBL3950169 — IC50 = 4.677 nM 8.33
CHEMBL3959573 — IC50 = 4.786 nM 8.32
CHEMBL3894762 — IC50 = 4.786 nM 8.32