Compound Detail
CHEMBL3911635
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COc1cc(OC)cc(N(CC(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1
Basic Information
| ChEMBL ID | CHEMBL3911635 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JXGGHGLZZYBWNG-UHFFFAOYSA-N |
5
Targets
8
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
501.5
MW (Da)
5.15
ALogP
8
HBA
1
HBD
85.5
PSA (Ų)
0.36
QED
2
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 8 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 9.0 | 8.175 | 1.0 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.56 | 7.775 | 2.8 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.55 | 8.55 | 2.8 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.49 | 8.49 | 3.2 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.87 | 6.18 | 134.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine