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Assay Detail

CHEMBL3880339

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human FGFR3 using Btn-Flt3 as substrate after 60 mins by TR-FRET assay
ChEMBL ↗
626
Total Activities
626
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fibroblast growth factor receptor 3 (CHEMBL2742) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazolyl quinoxaline kinase inhibitors
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 626 8.14 9.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3921618 — — 1 9.35
CHEMBL3937972 — — 1 9.31
CHEMBL3912569 — — 1 9.23
CHEMBL3913322 — — 1 9.21
CHEMBL3980232 — — 1 9.19
CHEMBL3951245 — — 1 9.15
CHEMBL3892776 — — 1 9.15
CHEMBL3919173 — — 1 9.14
CHEMBL3983918 — — 1 9.11
CHEMBL3951126 — — 1 9.10
CHEMBL3913757 — — 1 9.10
CHEMBL3935597 — — 1 9.10
CHEMBL3928393 — — 1 9.09
CHEMBL3905866 — — 1 9.08
CHEMBL3962492 — — 1 9.08
CHEMBL3909565 — — 1 9.07
CHEMBL3900574 — — 1 9.07
CHEMBL3925306 — — 1 9.06
CHEMBL3968009 — — 1 9.06
CHEMBL3912831 — — 1 9.06
CHEMBL3925081 — — 1 9.05
CHEMBL3985692 — — 1 9.04
CHEMBL3921441 — — 1 9.02
CHEMBL3969446 — — 1 9.01
CHEMBL3954298 — — 1 9.01
CHEMBL3959849 — — 1 9.01
CHEMBL3898908 — — 1 9.00
CHEMBL3911635 — — 1 9.00
CHEMBL3979013 — — 1 8.99
CHEMBL3898881 — — 1 8.97

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3921618 — IC50 = 0.4467 nM 9.35
CHEMBL3937972 — IC50 = 0.4898 nM 9.31
CHEMBL3912569 — IC50 = 0.5888 nM 9.23
CHEMBL3913322 — IC50 = 0.6166 nM 9.21
CHEMBL3980232 — IC50 = 0.6457 nM 9.19
CHEMBL3892776 — IC50 = 0.7079 nM 9.15
CHEMBL3951245 — IC50 = 0.7079 nM 9.15
CHEMBL3919173 — IC50 = 0.7244 nM 9.14
CHEMBL3983918 — IC50 = 0.7762 nM 9.11
CHEMBL3913757 — IC50 = 0.7943 nM 9.10
CHEMBL3935597 — IC50 = 0.7943 nM 9.10
CHEMBL3951126 — IC50 = 0.7943 nM 9.10
CHEMBL3928393 — IC50 = 0.8128 nM 9.09
CHEMBL3905866 — IC50 = 0.8318 nM 9.08
CHEMBL3962492 — IC50 = 0.8318 nM 9.08
CHEMBL3909565 — IC50 = 0.8511 nM 9.07
CHEMBL3900574 — IC50 = 0.8511 nM 9.07
CHEMBL3968009 — IC50 = 0.871 nM 9.06
CHEMBL3925306 — IC50 = 0.871 nM 9.06
CHEMBL3912831 — IC50 = 0.871 nM 9.06
CHEMBL3925081 — IC50 = 0.8913 nM 9.05
CHEMBL3985692 — IC50 = 0.912 nM 9.04
CHEMBL3921441 — IC50 = 0.955 nM 9.02
CHEMBL3969446 — IC50 = 0.9772 nM 9.01
CHEMBL3954298 — IC50 = 0.9772 nM 9.01
CHEMBL3959849 — IC50 = 0.9772 nM 9.01
CHEMBL3898908 — IC50 = 1.0 nM 9.00
CHEMBL3911635 — IC50 = 1.0 nM 9.00
CHEMBL3979013 — IC50 = 1.023 nM 8.99
CHEMBL3898881 — IC50 = 1.072 nM 8.97
CHEMBL3891892 — IC50 = 1.072 nM 8.97
CHEMBL3964574 — IC50 = 1.096 nM 8.96
CHEMBL3939764 — IC50 = 1.096 nM 8.96
CHEMBL3942594 — IC50 = 1.096 nM 8.96
CHEMBL3926556 — IC50 = 1.096 nM 8.96
CHEMBL3958153 — IC50 = 1.122 nM 8.95
CHEMBL3894762 — IC50 = 1.122 nM 8.95
CHEMBL3927327 — IC50 = 1.122 nM 8.95
CHEMBL3904674 — IC50 = 1.148 nM 8.94
CHEMBL3921457 — IC50 = 1.148 nM 8.94
CHEMBL3949470 — IC50 = 1.175 nM 8.93
CHEMBL3918751 — IC50 = 1.175 nM 8.93
CHEMBL3964096 — IC50 = 1.202 nM 8.92
CHEMBL3945373 — IC50 = 1.202 nM 8.92
CHEMBL3960877 — IC50 = 1.202 nM 8.92
CHEMBL3895267 — IC50 = 1.202 nM 8.92
CHEMBL3950910 — IC50 = 1.202 nM 8.92
CHEMBL3924172 — IC50 = 1.202 nM 8.92
CHEMBL3891525 — IC50 = 1.202 nM 8.92
CHEMBL3948321 — IC50 = 1.23 nM 8.91