Compound Detail
CHEMBL3925081
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[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1
Basic Information
| ChEMBL ID | CHEMBL3925081 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OOWSKBMTGLHFAR-BMSJAHLVSA-N |
| Parent Compound | CHEMBL3958153 |
| Active Moiety | CHEMBL3958153 |
6
Targets
9
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
405.5
MW (Da)
3.18
ALogP
8
HBA
1
HBD
85.5
PSA (Ų)
0.51
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 9 meas. best 9.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 9.05 | 7.96 | 0.9 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.58 | 7.585 | 2.6 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.37 | 8.37 | 4.3 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.24 | 8.24 | 5.8 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.08 | 6.365 | 83.2 | 2 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.1 | 5.1 | 7943.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine