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Assay Detail

CHEMBL3880342

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of FGFR1 (unknown origin) transfected in mouse BA/F3 cells assessed as decrease in cell proliferation in absence of mouse IL3 after 24 hrs by Alamar blue assay
ChEMBL ↗
646
Total Activities
646
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BaF3
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fibroblast growth factor receptor 1 (CHEMBL3650) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazolyl quinoxaline kinase inhibitors
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 646 6.60 9.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3976275 — — 1 9.22
CHEMBL3978754 — — 1 9.20
CHEMBL3903973 — — 1 8.63
CHEMBL3969667 — — 1 8.58
CHEMBL3921190 — — 1 8.55
CHEMBL3953833 — — 1 8.54
CHEMBL3894754 — — 1 8.44
CHEMBL3980417 — — 1 8.35
CHEMBL3927140 — — 1 8.32
CHEMBL3902353 — — 1 8.31
CHEMBL3982718 — — 1 8.22
CHEMBL3986068 — — 1 8.19
CHEMBL3893786 — — 1 8.17
CHEMBL3952789 — — 1 8.17
CHEMBL3980069 — — 1 8.15
CHEMBL3906894 — — 1 8.12
CHEMBL3953771 — — 1 8.11
CHEMBL3919479 — — 1 8.03
CHEMBL3926082 — — 1 8.02
CHEMBL3921476 — — 1 7.99
CHEMBL3902961 — — 1 7.98
CHEMBL3918092 — — 1 7.97
CHEMBL3970430 — — 1 7.97
CHEMBL3983694 — — 1 7.96
CHEMBL3955563 — — 1 7.93
CHEMBL3911621 — — 1 7.88
CHEMBL3968139 — — 1 7.86
CHEMBL3964574 — — 1 7.83
CHEMBL3968818 — — 1 7.82
CHEMBL3935597 — — 1 7.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3976275 — IC50 = 0.6026 nM 9.22
CHEMBL3978754 — IC50 = 0.631 nM 9.20
CHEMBL3903973 — IC50 = 2.344 nM 8.63
CHEMBL3969667 — IC50 = 2.63 nM 8.58
CHEMBL3921190 — IC50 = 2.818 nM 8.55
CHEMBL3953833 — IC50 = 2.884 nM 8.54
CHEMBL3894754 — IC50 = 3.631 nM 8.44
CHEMBL3980417 — IC50 = 4.467 nM 8.35
CHEMBL3927140 — IC50 = 4.786 nM 8.32
CHEMBL3902353 — IC50 = 4.898 nM 8.31
CHEMBL3982718 — IC50 = 6.026 nM 8.22
CHEMBL3986068 — IC50 = 6.457 nM 8.19
CHEMBL3893786 — IC50 = 6.761 nM 8.17
CHEMBL3952789 — IC50 = 6.761 nM 8.17
CHEMBL3980069 — IC50 = 7.079 nM 8.15
CHEMBL3906894 — IC50 = 7.586 nM 8.12
CHEMBL3953771 — IC50 = 7.762 nM 8.11
CHEMBL3919479 — IC50 = 9.333 nM 8.03
CHEMBL3926082 — IC50 = 9.55 nM 8.02
CHEMBL3921476 — IC50 = 10.23 nM 7.99
CHEMBL3902961 — IC50 = 10.47 nM 7.98
CHEMBL3918092 — IC50 = 10.72 nM 7.97
CHEMBL3970430 — IC50 = 10.72 nM 7.97
CHEMBL3983694 — IC50 = 10.96 nM 7.96
CHEMBL3955563 — IC50 = 11.75 nM 7.93
CHEMBL3911621 — IC50 = 13.18 nM 7.88
CHEMBL3968139 — IC50 = 13.8 nM 7.86
CHEMBL3964574 — IC50 = 14.79 nM 7.83
CHEMBL3935597 — IC50 = 15.14 nM 7.82
CHEMBL3968818 — IC50 = 15.14 nM 7.82
CHEMBL3918638 — IC50 = 15.49 nM 7.81
CHEMBL3947361 — IC50 = 15.49 nM 7.81
CHEMBL3921469 — IC50 = 15.85 nM 7.80
CHEMBL3943917 — IC50 = 15.85 nM 7.80
CHEMBL3897523 — IC50 = 16.22 nM 7.79
CHEMBL3945159 — IC50 = 16.22 nM 7.79
CHEMBL3892135 — IC50 = 16.22 nM 7.79
CHEMBL3945264 — IC50 = 16.6 nM 7.78
CHEMBL3907314 — IC50 = 16.6 nM 7.78
CHEMBL3942763 — IC50 = 17.38 nM 7.76
CHEMBL3979670 — IC50 = 17.78 nM 7.75
CHEMBL3932756 — IC50 = 18.2 nM 7.74
CHEMBL3921618 — IC50 = 18.2 nM 7.74
CHEMBL3919173 — IC50 = 18.2 nM 7.74
CHEMBL3939200 — IC50 = 19.05 nM 7.72
CHEMBL3964043 — IC50 = 19.05 nM 7.72
CHEMBL3984039 — IC50 = 19.05 nM 7.72
CHEMBL3933908 — IC50 = 19.05 nM 7.72
CHEMBL3901420 — IC50 = 19.5 nM 7.71
CHEMBL3905276 — IC50 = 19.95 nM 7.70