Compound Detail
CHEMBL3969667
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COc1cccnc1C#CCN(c1ccc2ncc(-c3cnn(C)c3)nc2c1)c1c(Cl)c(OC)cc(OC)c1Cl
Basic Information
| ChEMBL ID | CHEMBL3969667 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PPFQKJGJQXSDJS-UHFFFAOYSA-N |
5
Targets
8
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
575.5
MW (Da)
5.95
ALogP
9
HBA
0
HBD
87.4
PSA (Ų)
0.22
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 8 meas. best 8.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.58 | 8.38 | 2.6 | 2 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.23 | 8.035 | 5.9 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 7.91 | 7.91 | 12.3 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.45 | 7.45 | 35.5 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.11 | 6.085 | 77.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine