Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3880338

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human FGFR2 using Btn-Flt3 as substrate after 60 mins by TR-FRET assay
ChEMBL ↗
621
Total Activities
621
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fibroblast growth factor receptor 2 (CHEMBL4142) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazolyl quinoxaline kinase inhibitors
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 621 8.01 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3960877 — — 1 9.05
CHEMBL3958209 — — 1 8.98
CHEMBL3934260 — — 1 8.95
CHEMBL3966748 — — 1 8.93
CHEMBL3919479 — — 1 8.90
CHEMBL3904674 — — 1 8.86
CHEMBL3936672 — — 1 8.86
CHEMBL3899151 — — 1 8.85
CHEMBL3912569 — — 1 8.84
CHEMBL3942328 — — 1 8.82
CHEMBL3907314 — — 1 8.81
CHEMBL3910444 — — 1 8.81
CHEMBL3931421 — — 1 8.80
CHEMBL3935597 — — 1 8.79
CHEMBL3908149 — — 1 8.78
CHEMBL3918092 — — 1 8.78
CHEMBL3893786 — — 1 8.77
CHEMBL3906894 — — 1 8.76
CHEMBL3918638 — — 1 8.76
CHEMBL3985222 — — 1 8.75
CHEMBL3968499 — — 1 8.75
CHEMBL3945159 — — 1 8.75
CHEMBL3965710 — — 1 8.75
CHEMBL3968124 — — 1 8.75
CHEMBL3911621 — — 1 8.75
CHEMBL3919173 — — 1 8.74
CHEMBL3959573 — — 1 8.74
CHEMBL3964574 — — 1 8.74
CHEMBL3913322 — — 1 8.74
CHEMBL3975447 — — 1 8.73

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3960877 — IC50 = 0.8913 nM 9.05
CHEMBL3958209 — IC50 = 1.047 nM 8.98
CHEMBL3934260 — IC50 = 1.122 nM 8.95
CHEMBL3966748 — IC50 = 1.175 nM 8.93
CHEMBL3919479 — IC50 = 1.259 nM 8.90
CHEMBL3936672 — IC50 = 1.38 nM 8.86
CHEMBL3904674 — IC50 = 1.38 nM 8.86
CHEMBL3899151 — IC50 = 1.413 nM 8.85
CHEMBL3912569 — IC50 = 1.445 nM 8.84
CHEMBL3942328 — IC50 = 1.514 nM 8.82
CHEMBL3907314 — IC50 = 1.549 nM 8.81
CHEMBL3910444 — IC50 = 1.549 nM 8.81
CHEMBL3931421 — IC50 = 1.585 nM 8.80
CHEMBL3935597 — IC50 = 1.622 nM 8.79
CHEMBL3918092 — IC50 = 1.66 nM 8.78
CHEMBL3908149 — IC50 = 1.66 nM 8.78
CHEMBL3893786 — IC50 = 1.698 nM 8.77
CHEMBL3918638 — IC50 = 1.738 nM 8.76
CHEMBL3906894 — IC50 = 1.738 nM 8.76
CHEMBL3968499 — IC50 = 1.778 nM 8.75
CHEMBL3985222 — IC50 = 1.778 nM 8.75
CHEMBL3965710 — IC50 = 1.778 nM 8.75
CHEMBL3945159 — IC50 = 1.778 nM 8.75
CHEMBL3968124 — IC50 = 1.778 nM 8.75
CHEMBL3911621 — IC50 = 1.778 nM 8.75
CHEMBL3919173 — IC50 = 1.82 nM 8.74
CHEMBL3964574 — IC50 = 1.82 nM 8.74
CHEMBL3959573 — IC50 = 1.82 nM 8.74
CHEMBL3913322 — IC50 = 1.82 nM 8.74
CHEMBL3948744 — IC50 = 1.862 nM 8.73
CHEMBL3918739 — IC50 = 1.862 nM 8.73
CHEMBL3975447 — IC50 = 1.862 nM 8.73
CHEMBL3928393 — IC50 = 1.905 nM 8.72
CHEMBL3955563 — IC50 = 1.905 nM 8.72
CHEMBL3968818 — IC50 = 1.905 nM 8.72
CHEMBL3903811 — IC50 = 1.905 nM 8.72
CHEMBL3968139 — IC50 = 1.95 nM 8.71
CHEMBL3922698 — IC50 = 1.95 nM 8.71
CHEMBL3984039 — IC50 = 1.95 nM 8.71
CHEMBL3919730 — IC50 = 1.95 nM 8.71
CHEMBL3894762 — IC50 = 1.95 nM 8.71
CHEMBL3983996 — IC50 = 1.995 nM 8.70
CHEMBL3951694 — IC50 = 1.995 nM 8.70
CHEMBL3905866 — IC50 = 1.995 nM 8.70
CHEMBL3943860 — IC50 = 1.995 nM 8.70
CHEMBL3909529 — IC50 = 2.042 nM 8.69
CHEMBL3937972 — IC50 = 2.042 nM 8.69
CHEMBL3942763 — IC50 = 2.042 nM 8.69
CHEMBL3971277 — IC50 = 2.089 nM 8.68
CHEMBL3966305 — IC50 = 2.089 nM 8.68