Compound Detail
CHEMBL3913322
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COc1cc(OC)cc(N(C[C@@H](O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1
Basic Information
| ChEMBL ID | CHEMBL3913322 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | INWHLZUNIJSPHA-JOCHJYFZSA-N |
5
Targets
7
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
473.5
MW (Da)
4.11
ALogP
8
HBA
1
HBD
85.5
PSA (Ų)
0.43
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 9.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 9.21 | 9.21 | 0.6 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.93 | 8.115 | 1.2 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.74 | 8.74 | 1.8 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.6 | 8.6 | 2.5 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.86 | 6.175 | 138.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine