Compound Detail
CHEMBL3901420
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CNC(=O)c1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cnn(C(C)C)c4)nc3c2)c1
Basic Information
| ChEMBL ID | CHEMBL3901420 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RGYNBLDJVUWGQS-UHFFFAOYSA-N |
6
Targets
9
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
501.6
MW (Da)
4.58
ALogP
8
HBA
2
HBD
97.2
PSA (Ų)
0.33
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 9 meas. best 8.13
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.13 | 8.13 | 7.4 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.1 | 8.05 | 7.9 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.08 | 7.895 | 8.3 | 2 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.55 | 7.55 | 28.2 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.46 | 7.2 | 34.7 | 2 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.68 | 5.68 | 2089.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine