Compound Detail
CHEMBL3983918
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COc1cc(OC)cc(N(CCCNC(=O)C(F)(F)F)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1.O=C(O)C(F)(F)F
Basic Information
| ChEMBL ID | CHEMBL3983918 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WMIKNCHTXHYPGV-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3990333 |
| Active Moiety | CHEMBL3990333 |
5
Targets
9
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
500.5
MW (Da)
4.24
ALogP
7
HBA
2
HBD
105.3
PSA (Ų)
0.33
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 9 meas. best 9.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 9.12 | 7.2233 | 0.8 | 3 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 9.11 | 8.05 | 0.8 | 2 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.79 | 8.79 | 1.6 | 1 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.53 | 8.53 | 3.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.47 | 6.8 | 33.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine