Compound Detail
CHEMBL3927327
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
COc1cc(OC)cc(N(CC2CC2)c2ccc3ncc(-c4cnn(CCCN5CCOCC5)c4)nc3c2)c1.Cl
Basic Information
| ChEMBL ID | CHEMBL3927327 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PZJWQXFQJHDXPN-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3990444 |
| Active Moiety | CHEMBL3990444 |
5
Targets
7
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
528.7
MW (Da)
4.78
ALogP
9
HBA
0
HBD
77.8
PSA (Ų)
0.28
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 8.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.95 | 7.67 | 1.1 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.53 | 7.14 | 3.0 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.14 | 8.14 | 7.2 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.64 | 7.64 | 22.9 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.68 | 6.68 | 208.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine