Compound Detail
CHEMBL3897101
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COc1cc(OC)cc(N(CCCNC(=O)C(C)(O)C(F)(F)F)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1
Basic Information
| ChEMBL ID | CHEMBL3897101 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KRYZCYZIWKIKGN-UHFFFAOYSA-N |
5
Targets
8
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
558.6
MW (Da)
4.01
ALogP
9
HBA
2
HBD
114.6
PSA (Ų)
0.28
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 8 meas. best 8.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.77 | 7.76 | 1.7 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.77 | 7.8 | 1.7 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.55 | 8.55 | 2.8 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.68 | 6.825 | 20.9 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine