Compound Detail
CHEMBL3981418
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Cl.[2H]C([2H])([2H])Oc1cc(OC)cc(N(CCNC(C)C)c2ccc3ncc(-c4cn[nH]c4)nc3c2)c1
Basic Information
| ChEMBL ID | CHEMBL3981418 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LROUZHGAXKBMPL-FJCVKDQNSA-N |
| Parent Compound | CHEMBL3990373 |
| Active Moiety | CHEMBL3990373 |
5
Targets
8
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
432.5
MW (Da)
4.17
ALogP
7
HBA
2
HBD
88.2
PSA (Ų)
0.41
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 8 meas. best 8.91
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.91 | 7.975 | 1.2 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.55 | 8.55 | 2.8 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.52 | 7.92 | 3.0 | 2 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.22 | 8.22 | 6.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.26 | 6.535 | 55.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine