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Assay Detail

CHEMBL3880345

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of FGFR3 (unknown origin) transfected in mouse BA/F3 cells assessed as decrease in cell proliferation in presence of mouse IL3 after 24 hrs by Alamar blue assay
ChEMBL ↗
635
Total Activities
635
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type BaF3
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fibroblast growth factor receptor 3 (CHEMBL2742) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrazolyl quinoxaline kinase inhibitors
(2014)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 635 5.20 5.69

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3979972 — — 1 5.69
CHEMBL3902961 — — 1 5.63
CHEMBL3982399 — — 1 5.61
CHEMBL3964043 — — 1 5.59
CHEMBL3964762 — — 1 5.56
CHEMBL3904441 — — 1 5.50
CHEMBL3906253 — — 1 5.44
CHEMBL3959787 — — 1 5.38
CHEMBL3970423 — — 1 5.36
CHEMBL3918800 — — 1 5.34
CHEMBL3908829 — — 1 5.33
CHEMBL3964931 — — 1 5.33
CHEMBL3948321 — — 1 5.29
CHEMBL3943933 — — 1 5.29
CHEMBL3945369 — — 1 5.28
CHEMBL3902434 — — 1 5.28
CHEMBL3931381 — — 1 5.28
CHEMBL3985853 — — 1 5.28
CHEMBL3969446 — — 1 5.27
CHEMBL3964675 — — 1 5.27
CHEMBL3908326 — — 1 5.26
CHEMBL3960128 — — 1 5.26
CHEMBL3925306 — — 1 5.25
CHEMBL3976280 — — 1 5.25
CHEMBL3937533 — — 1 5.25
CHEMBL3962814 — — 1 5.25
CHEMBL3915268 — — 1 5.25
CHEMBL3921197 — — 1 5.25
CHEMBL3973263 — — 1 5.25
CHEMBL3917908 — — 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3979972 — IC50 = 2041.74 nM 5.69
CHEMBL3902961 — IC50 = 2344.23 nM 5.63
CHEMBL3982399 — IC50 = 2454.71 nM 5.61
CHEMBL3964043 — IC50 = 2570.4 nM 5.59
CHEMBL3964762 — IC50 = 2754.23 nM 5.56
CHEMBL3904441 — IC50 = 3162.28 nM 5.50
CHEMBL3906253 — IC50 = 3630.78 nM 5.44
CHEMBL3959787 — IC50 = 4168.69 nM 5.38
CHEMBL3970423 — IC50 = 4365.16 nM 5.36
CHEMBL3918800 — IC50 = 4570.88 nM 5.34
CHEMBL3908829 — IC50 = 4677.35 nM 5.33
CHEMBL3964931 — IC50 = 4677.35 nM 5.33
CHEMBL3948321 — IC50 = 5128.61 nM 5.29
CHEMBL3943933 — IC50 = 5128.61 nM 5.29
CHEMBL3902434 — IC50 = 5248.07 nM 5.28
CHEMBL3945369 — IC50 = 5248.07 nM 5.28
CHEMBL3931381 — IC50 = 5248.07 nM 5.28
CHEMBL3985853 — IC50 = 5248.07 nM 5.28
CHEMBL3964675 — IC50 = 5370.32 nM 5.27
CHEMBL3969446 — IC50 = 5370.32 nM 5.27
CHEMBL3960128 — IC50 = 5495.41 nM 5.26
CHEMBL3908326 — IC50 = 5495.41 nM 5.26
CHEMBL3973263 — IC50 = 5623.41 nM 5.25
CHEMBL3976280 — IC50 = 5623.41 nM 5.25
CHEMBL3925306 — IC50 = 5623.41 nM 5.25
CHEMBL3921197 — IC50 = 5623.41 nM 5.25
CHEMBL3917908 — IC50 = 5623.41 nM 5.25
CHEMBL3937533 — IC50 = 5623.41 nM 5.25
CHEMBL3962814 — IC50 = 5623.41 nM 5.25
CHEMBL3915268 — IC50 = 5623.41 nM 5.25
CHEMBL3898120 — IC50 = 5754.4 nM 5.24
CHEMBL3898926 — IC50 = 5754.4 nM 5.24
CHEMBL3896249 — IC50 = 5888.44 nM 5.23
CHEMBL3956164 — IC50 = 5888.44 nM 5.23
CHEMBL3958708 — IC50 = 6025.6 nM 5.22
CHEMBL3979328 — IC50 = 6165.95 nM 5.21
CHEMBL3905048 — IC50 = 6165.95 nM 5.21
CHEMBL3974080 — IC50 = 6165.95 nM 5.21
CHEMBL3946674 — IC50 = 6309.57 nM 5.20
CHEMBL3918739 — IC50 = 6456.54 nM 5.19
CHEMBL3927140 — IC50 = 6606.93 nM 5.18
CHEMBL3971277 — IC50 = 6760.83 nM 5.17
CHEMBL3951360 — IC50 = 6760.83 nM 5.17
CHEMBL3947361 — IC50 = 6918.31 nM 5.16
CHEMBL3945264 — IC50 = 6918.31 nM 5.16
CHEMBL3969408 — IC50 = 7079.46 nM 5.15
CHEMBL3921469 — IC50 = 7079.46 nM 5.15
CHEMBL3893070 — IC50 = 7079.46 nM 5.15
CHEMBL3943860 — IC50 = 7079.46 nM 5.15
CHEMBL3969824 — IC50 = 7079.46 nM 5.15