Compound Detail
CHEMBL3958708
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COc1cc(OC)cc(N(CCN2CCC(N(C)C)C2)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1
Basic Information
| ChEMBL ID | CHEMBL3958708 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AYLGNVUDASUDAB-UHFFFAOYSA-N |
5
Targets
9
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
501.6
MW (Da)
3.82
ALogP
9
HBA
0
HBD
71.8
PSA (Ų)
0.34
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 9 meas. best 8.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.74 | 7.59 | 1.8 | 2 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.5 | 6.7733 | 3.2 | 3 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.47 | 8.47 | 3.4 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.05 | 8.05 | 8.9 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.13 | 6.41 | 74.1 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine