Compound Detail
CHEMBL3890896
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Basic Information
| ChEMBL ID | CHEMBL3890896 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DYBBAKRYVKNMJY-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3990963 |
| Active Moiety | CHEMBL3990963 |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
434.5
MW (Da)
2.60
ALogP
9
HBA
2
HBD
111.5
PSA (Ų)
0.41
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.82 | 8.0867 | 1.5 | 3 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.57 | 7.57 | 26.9 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 6.84 | 6.84 | 144.5 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.1 | 6.1 | 794.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 1.514 | nM | 8.82 | Inhibition of recombinant human N-terminal His6-tagged FGFR3 expressed in insect... | - |
| Fibroblast growth factor receptor 3 | IC50 | = | 2.692 | nM | 8.57 | Inhibition of TEL-fused FGFR3 (unknown origin) transfected in mouse BA/F3 cells ... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 26.92 | nM | 7.57 | Inhibition of recombinant human N-terminal His6-tagged VEGFR2 (790 end residues)... | - |
| Fibroblast growth factor receptor 3 | IC50 | = | 134.9 | nM | 6.87 | Inhibition of FGFR3 (unknown origin) transfected in mouse BA/F3 cells assessed a... | - |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 144.54 | nM | 6.84 | Inhibition of FLT3 (unknown origin) transfected in mouse BA/F3 cells assessed as... | - |
| Fibroblast growth factor receptor 1 | IC50 | = | 794.33 | nM | 6.1 | Inhibition of FGFR1 (unknown origin) transfected in mouse BA/F3 cells assessed a... | - |
Data from ChEMBL 36 via Core Engine