Compound Detail
CHEMBL3932363
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CNCCN(c1cc(OC)cc(OC)c1)c1ccc2ncc(-c3cnn(CC4CCOCC4)c3)nc2c1.Cl
Basic Information
| ChEMBL ID | CHEMBL3932363 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZFKDHRXSKPFOCM-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3990543 |
| Active Moiety | CHEMBL3990543 |
5
Targets
8
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
502.6
MW (Da)
4.29
ALogP
9
HBA
1
HBD
86.6
PSA (Ų)
0.34
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 8 meas. best 8.25
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.25 | 7.855 | 5.6 | 2 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.2 | 8.005 | 6.3 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.19 | 8.19 | 6.5 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 7.66 | 7.66 | 21.9 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.39 | 6.74 | 40.7 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine