Compound Detail
CHEMBL3907195
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COc1cc(OC)cc(N(CCN2CCC[C@H]2CO)c2ccc3ncc(-c4cnn(C)c4)nc3c2)c1
Basic Information
| ChEMBL ID | CHEMBL3907195 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MJBNLVZGJYYOOP-NRFANRHFSA-N |
5
Targets
11
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
488.6
MW (Da)
3.64
ALogP
9
HBA
1
HBD
88.8
PSA (Ų)
0.38
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 11 meas. best 9.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 9.04 | 8.5725 | 0.9 | 4 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 8.69 | 8.005 | 2.0 | 2 |
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 8.61 | 8.61 | 2.5 | 1 |
| Fibroblast growth factor receptor 4 CHEMBL3973 | IC50 | 8.08 | 8.08 | 8.3 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.6 | 6.9167 | 25.1 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine