Compound Detail
CHEMBL3985332
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3985332 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AWTSJGWLNSLHGG-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3956571 |
| Active Moiety | CHEMBL3956571 |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
409.9
MW (Da)
3.82
ALogP
7
HBA
1
HBD
76.3
PSA (Ų)
0.52
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 8.44 | 8.18 | 3.6 | 2 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.04 | 7.04 | 91.2 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.72 | 5.72 | 1905.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 3.631 | nM | 8.44 | Inhibition of recombinant human N-terminal His6-tagged FGFR3 expressed in insect... | - |
| Fibroblast growth factor receptor 3 | IC50 | = | 12.02 | nM | 7.92 | Inhibition of TEL-fused FGFR3 (unknown origin) transfected in mouse BA/F3 cells ... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 91.2 | nM | 7.04 | Inhibition of recombinant human N-terminal His6-tagged VEGFR2 (790 end residues)... | - |
| NON-PROTEIN TARGET | IC50 | = | 1905.46 | nM | 5.72 | Antiproliferative activity against mouse BA/F3 cells in presence of mouse IL3 af... | - |
Data from ChEMBL 36 via Core Engine