Compound Detail
CHEMBL3955800
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Basic Information
| ChEMBL ID | CHEMBL3955800 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GLACKZZDEYNOLO-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3931421 |
| Active Moiety | CHEMBL3931421 |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
458.6
MW (Da)
4.66
ALogP
7
HBA
1
HBD
79.4
PSA (Ų)
0.39
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 9.29 | 9.125 | 0.5 | 2 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.7 | 7.7 | 19.9 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 5.64 | 5.64 | 2290.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 0.5129 | nM | 9.29 | Inhibition of recombinant human N-terminal His6-tagged FGFR3 expressed in insect... | - |
| Fibroblast growth factor receptor 3 | IC50 | = | 1.096 | nM | 8.96 | Inhibition of TEL-fused FGFR3 (unknown origin) transfected in mouse BA/F3 cells ... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 19.95 | nM | 7.7 | Inhibition of recombinant human N-terminal His6-tagged VEGFR2 (790 end residues)... | - |
| NON-PROTEIN TARGET | IC50 | = | 2290.87 | nM | 5.64 | Antiproliferative activity against mouse BA/F3 cells in presence of mouse IL3 af... | - |
Data from ChEMBL 36 via Core Engine