Compound Detail
CHEMBL3969061
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Basic Information
| ChEMBL ID | CHEMBL3969061 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LUDGMVDSCQQOMP-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
417.5
MW (Da)
4.84
ALogP
7
HBA
0
HBD
65.3
PSA (Ų)
0.43
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 7.77 | 7.31 | 17.0 | 2 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 5.96 | 5.96 | 1096.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 16.98 | nM | 7.77 | Inhibition of recombinant human N-terminal His6-tagged FGFR3 expressed in insect... | - |
| Fibroblast growth factor receptor 3 | IC50 | = | 141.25 | nM | 6.85 | Inhibition of TEL-fused FGFR3 (unknown origin) transfected in mouse BA/F3 cells ... | - |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 1096.48 | nM | 5.96 | Inhibition of recombinant human N-terminal His6-tagged VEGFR2 (790 end residues)... | - |
Data from ChEMBL 36 via Core Engine