Compound Detail
CHEMBL3934596
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Basic Information
| ChEMBL ID | CHEMBL3934596 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CZMWGXOYAYNAFA-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
460.6
MW (Da)
4.80
ALogP
7
HBA
0
HBD
59.3
PSA (Ų)
0.38
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 9.1 | 8.9 | 0.8 | 2 |
| NON-PROTEIN TARGET CHEMBL3879801 | IC50 | 6.23 | 6.23 | 588.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 3 | IC50 | = | 0.7943 | nM | 9.1 | Inhibition of TEL-fused FGFR3 (unknown origin) transfected in mouse BA/F3 cells ... | - |
| Fibroblast growth factor receptor 3 | IC50 | = | 1.995 | nM | 8.7 | Inhibition of recombinant human N-terminal His6-tagged FGFR3 expressed in insect... | - |
| NON-PROTEIN TARGET | IC50 | = | 588.84 | nM | 6.23 | Antiproliferative activity against mouse BA/F3 cells in presence of mouse IL3 af... | - |
Data from ChEMBL 36 via Core Engine