Compound Detail
CHEMBL3948855
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Basic Information
| ChEMBL ID | CHEMBL3948855 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YYQCTPAAXICISH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
430.5
MW (Da)
1.91
ALogP
9
HBA
1
HBD
98.2
PSA (Ų)
0.67
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform CHEMBL3145 | IC50 | 6.26 | 6.26 | 554.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | IC50 | = | 554.0 | nM | 6.26 | Inhibition of PI3Kbeta (unknown origin) expressed in Escherichia coli-infected f... | 27387421 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27387421 | 10.1016/j.ejmech.2016.06.010 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1 |
| 27387421 | 10.1016/j.ejmech.2016.06.010 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1 |
Data from ChEMBL 36 via Core Engine