Assay Detail
Binding
CHEMBL3866409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kbeta (unknown origin) expressed in Escherichia coli-infected fall armyworm sf21 cells co-expressing p85 by kinase-glo luminescence assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.22 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 8.22 |
| CHEMBL3982304 | — | — | 1 | 7.44 |
| CHEMBL1972466 | — | — | 1 | 7.28 |
| CHEMBL3949883 | — | — | 1 | 6.72 |
| CHEMBL3930788 | — | — | 1 | 6.44 |
| CHEMBL3922132 | — | — | 1 | 6.37 |
| CHEMBL3963433 | — | — | 1 | 6.28 |
| CHEMBL3917147 | — | — | 1 | 6.27 |
| CHEMBL3948855 | — | — | 1 | 6.26 |
| CHEMBL3958556 | — | — | 1 | 6.09 |
| CHEMBL3893326 | — | — | 1 | 6.02 |
| CHEMBL3972268 | — | — | 1 | 5.97 |
| CHEMBL3978019 | — | — | 1 | 5.92 |
| CHEMBL3962354 | — | — | 1 | 5.88 |
| CHEMBL3974302 | — | — | 1 | 5.75 |
| CHEMBL3908177 | — | — | 1 | 5.70 |
| CHEMBL3900274 | — | — | 1 | 5.67 |
| CHEMBL3936124 | — | — | 1 | 5.50 |
| CHEMBL3953591 | — | — | 1 | 5.49 |
| CHEMBL3935927 | — | — | 1 | 5.15 |
| CHEMBL3944869 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL586702 | ZSTK-474 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3982304 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1972466 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3949883 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL3930788 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL3922132 | — | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL3963433 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL3917147 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL3948855 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL3958556 | — | IC50 | = | 811.0 | nM | 6.09 |
| CHEMBL3893326 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL3972268 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL3978019 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL3962354 | — | IC50 | = | 1328.0 | nM | 5.88 |
| CHEMBL3974302 | — | IC50 | = | 1797.0 | nM | 5.75 |
| CHEMBL3908177 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3900274 | — | IC50 | = | 2114.0 | nM | 5.67 |
| CHEMBL3936124 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL3953591 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL3935927 | — | IC50 | = | 7052.0 | nM | 5.15 |
| CHEMBL3944869 | — | IC50 | > | 10000.0 | nM | - |