Compound Detail
CHEMBL395100
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Basic Information
| ChEMBL ID | CHEMBL395100 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AACDUZATGDPUNH-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
288.3
MW (Da)
2.53
ALogP
7
HBA
2
HBD
92.5
PSA (Ų)
0.70
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Methionine aminopeptidase 2 CHEMBL3922 | Ki | 8.82 | 8.82 | 1.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Methionine aminopeptidase 2 | Ki | = | 1.5 | nM | 8.82 | Inhibition of human recombinant MetAP2 | 17636946 |
| Methionine aminopeptidase 2 | Ki | = | 1.514 | nM | 8.82 | Inhibition of methionine aminopeptidase 2 (unknown origin) | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17636946 | 10.1021/jm061182w | Methionine aminopeptidase 2 | 1 |
| - | 10.1039/C5MD00566C | Methionine aminopeptidase 2 | 1 |
Data from ChEMBL 36 via Core Engine