Compound Detail
CHEMBL3953466
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Basic Information
| ChEMBL ID | CHEMBL3953466 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RXBBGCUTEXDBEI-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
368.4
MW (Da)
4.28
ALogP
7
HBA
0
HBD
78.4
PSA (Ų)
0.21
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 CHEMBL4633 | EC50 | 7.3 | 7.3 | 50.0 | 1 |
| Potassium voltage-gated channel subfamily A member 5 CHEMBL4306 | EC50 | 6.8 | 6.8 | 159.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily A member 3 | EC50 | = | 50.0 | nM | 7.3 | Inhibition of Kv1.3 (unknown origin) | - |
| Potassium voltage-gated channel subfamily A member 5 | EC50 | = | 159.0 | nM | 6.8 | Inhibition of Kv1.5 (unknown origin) | - |
Data from ChEMBL 36 via Core Engine